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A rationale for intraperitoneally administered antibiotic therapy

Surgery, Gynecology & Obstetrics

|October 1, 1976

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Intraperitoneal administration of cephalothin in bacterial peritonitis patients resulted in a 96.7% satisfactory clinical response. This antibiotic regimen effectively lowered the death rate with minimal adverse effects.

Area of Science:

Infectious Diseases
Surgical Infections
Pharmacology

Background:

Bacterial peritonitis presents a significant challenge in surgical settings.
Effective antimicrobial strategies are crucial for managing peritonitis and improving patient outcomes.

Purpose of the Study:

To evaluate the efficacy and safety of intraperitoneal cephalothin for treating bacterial peritonitis.
To assess the impact of cephalothin on clinical response, mortality, and potential complications.

Main Methods:

A study involving 210 patients with confirmed bacterial peritonitis.
Treatment included surgical intervention and intraperitoneal administration of 1% cephalothin, with supplementary antibiotics as needed.

Main Results:

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A satisfactory clinical response was observed in 96.7% of patients.
Intraperitoneal cephalothin achieved high therapeutic levels with broad activity and minimal toxicity.
No significant peritoneal adhesions or abdominal pain were reported; potential promotion of anastomotic leak healing was noted.

Conclusions:

Intraperitoneal cephalothin is an effective treatment for bacterial peritonitis, significantly reducing mortality.
This approach offers therapeutic benefits, broad-spectrum activity, and safety, allowing for flexible additional antimicrobial therapy.