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Hyperthermic reaction to haloperidol with rigidity, associated to central core disease
E E Calore1, M J Cavaliere, N M Perez
1Instituto Adolfo Lutz, Divisao De Patologia Da Universidade De Sao Paulo, Complexo Hospitalar Mandaqui.
Acta Neurologica
|August 1, 1994
Summary
A patient experienced a severe reaction, including hyperthermia and rigidity, after taking haloperidol. This case highlights a potential link between haloperidol-induced hyperthermia and central core disease, a genetic muscle disorder.
Area of Science:
- Neurology
- Pharmacology
- Genetics
Background:
- Antipsychotic medications like haloperidol are crucial for managing psychotic disorders.
- Adverse drug reactions, including hyperthermia and muscular rigidity, can occur following haloperidol administration.
- Central core disease is a congenital myopathy associated with an increased risk of Malignant Hyperthermia.
Observation:
- A 21-year-old female presented with psychotic symptoms and subsequently developed hyperthermia, muscular rigidity, and hypertension post-haloperidol administration.
- Muscle biopsy revealed atrophic and necrotic fibers, with a significant number of fibers exhibiting central cores in oxidative enzyme preparations.
- The patient's clinical presentation and biopsy findings suggest a hyperthermic syndrome potentially linked to haloperidol exposure.
Findings:
- The case demonstrates an association between a haloperidol-induced hyperthermic syndrome and central core disease.
- This finding suggests that individuals with central core disease may be susceptible to specific adverse reactions from haloperidol.
- The presence of central cores in muscle fibers is a key diagnostic indicator.
Implications:
- This case underscores the importance of considering genetic predispositions, such as central core disease, when patients exhibit severe reactions to antipsychotic drugs.
- Further research is warranted to elucidate the precise mechanisms underlying the interaction between haloperidol and central core disease.
- Clinicians should be vigilant for potential hyperthermic syndromes in patients with psychotic symptoms and a history or suspicion of central core disease, especially when initiating haloperidol treatment.