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Hyperthermic reaction to haloperidol with rigidity, associated to central core disease
E E Calore1, M J Cavaliere, N M Perez
1Instituto Adolfo Lutz, Divisao De Patologia Da Universidade De Sao Paulo, Complexo Hospitalar Mandaqui.
Acta Neurologica
|August 1, 1994
Abstract:
A 21-year-old female patient with psychotic symptoms developed hyperthermia, muscular rigidity and hypertension after administration of haloperidol. A muscle biopsy showed some atrophic and necrotic fibers, and a great number of fibers with central cores in the oxidative enzyme preparations. A related syndrome, Malignant Hyperthermia (MH), is sometimes associated with central core disease. The present case shows an association of a hyperthermic syndrome related to haloperidol with central core disease.