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Related Experiment Videos

Does "incessant" ovulation increase risk for early menopause?

D W Cramer1, H Xu, B L Harlow

  • 1Ob-Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, MA 02115.

American Journal of Obstetrics and Gynecology
|February 1, 1995
PubMed
Summary
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Women experiencing early menopause often had earlier puberty, shorter cycles, fewer live births, and more pelvic surgeries. This suggests a pattern of rapid egg loss due to more frequent ovulation.

Area of Science:

  • Reproductive endocrinology
  • Gynecologic oncology
  • Epidemiology

Background:

  • Early menopause, defined as menopause before age 40, affects approximately 10% of women.
  • Understanding the factors contributing to early menopause is crucial for reproductive health and long-term well-being.

Purpose of the Study:

  • To investigate differences in gynecologic and reproductive histories between women who experienced early menopause and those who did not.
  • To identify potential predictors of early menopause.

Main Methods:

  • A case-control study involving 344 women with early menopause (average age 42.2 years) and 344 age-matched controls.
  • Data collected through interviews on reproductive history from a larger survey of women aged 45-54.

Main Results:

Related Experiment Videos

  • Women with early menopause were more likely to have had menarche at or before age 11, shorter menstrual cycles, fewer live births, and more pelvic surgeries (including oophorectomy and cesarean sections).
  • A higher number of presumed ovulatory cycles, estimated from menarche age, cycle length, and anovulation periods, was a significant predictor of early menopause.
  • This association remained significant in multivariate models, particularly after an estimated 300 ovulations.

Conclusions:

  • The reproductive histories of women with early menopause indicate a pattern of accelerated oocyte depletion, termed "incessant" ovulation.
  • This finding suggests that the cumulative number of ovulatory cycles may play a significant role in the timing of menopause.