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Related Experiment Videos

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar

A Desmoulière1, M Redard, I Darby

  • 1Department of Pathology, University of Geneva, Switzerland.

The American Journal of Pathology
|January 1, 1995
PubMed
Summary
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Apoptosis, programmed cell death, drives myofibroblast disappearance during wound healing. This cellular loss is key to granulation tissue transforming into scar tissue, impacting scar formation.

Area of Science:

  • Cell Biology
  • Wound Healing Research
  • Tissue Regeneration

Background:

  • Granulation tissue formation and contraction are crucial for second intention wound healing.
  • This tissue comprises vessels, inflammatory cells, fibroblasts, and myofibroblasts.
  • A significant decrease in cellularity, particularly myofibroblasts, occurs as wounds heal into scars.

Purpose of the Study:

  • To investigate the mechanism behind myofibroblast disappearance during wound healing.
  • To test the hypothesis that apoptosis is responsible for myofibroblast reduction.
  • To understand the role of programmed cell death in scar development.

Main Methods:

  • Morphometric analysis at the electron microscopic level.
  • In situ end labeling of fragmented DNA to detect apoptosis.

Related Experiment Videos

  • Quantification of apoptotic cells in granulation tissue during wound closure.

    • Main Results:

    • The number of myofibroblastic and vascular cells undergoing apoptosis increases as the wound closes.
    • These findings support apoptosis as the mechanism for myofibroblast disappearance.
    • The study provides evidence for programmed cell death in granulation tissue evolution.

    Conclusions:

    • Apoptosis is the primary mechanism responsible for the decrease in myofibroblasts during wound healing.
    • This cellular process is integral to the transformation of granulation tissue into scar tissue.
    • Regulating apoptosis during wound healing may be critical for preventing pathological scarring.