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Analytical and chemical profile of pidotimod
T Crimella1, R Orlandi, G Bocchiola
1Analytical Department, Poli Industria Chimica S.p.A., Milan, Italy.
Arzneimittel-Forschung
|December 1, 1994
Abstract:
Pidotimod ((R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-thiazolidine- 4-carboxylic acid, PGT/1A, CAS 121808-62-6) is a new synthetic immunostimulant, which has proved to possess a high activity. This paper describes its physico-chemical properties, structural identification including polymorphism, detection of impurities, determination of related compounds, separation, quantification and purity assay using high-performance liquid chromatography (HPLC).