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Genotoxicity testing of pidotimod in vitro and in vivo
K Adams1, J A Allen, P C Brooker
1Department of Mutagenesis and Cell Biology, Huntingdon Research Centre Ltd., England.
Arzneimittel-Forschung
|December 1, 1994
Abstract:
The mutagenic potential of pidotimod ((R)-3-[(S)-(5-oxo-2- pyrrolidinyl)carbonyl]-thiazolidine-4-carboxylic acid, PGT/1A, CAS 121808-62-6) was assessed in a series of five assays designed to measure gene mutation, chromosomal damage and primary DNA damage. All tests were carried out in accordance with appropriate EEC and OECD Guidelines. No indications of mutagenic potential were observed in any of the assays.