P-glycoprotein. To flip or not to flip?

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Updated: Aug 16, 2026

Determining Membrane Protein Topology Using Fluorescence Protease Protection (FPP)
08:14

Determining Membrane Protein Topology Using Fluorescence Protease Protection (FPP)

Published on: April 20, 2015

C F Higgins1

  • 1Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, Oxford, UK.

Current Biology : CB
|March 1, 1994
PubMed

Insights

Mice with mutations in the mdr2 gene show a distinct phenotype. This suggests the mdr2 protein plays a crucial role in phospholipid transport.

Area of Science:

  • Biochemistry
  • Genetics
  • Molecular Biology

Background:

  • The mdr2 gene encodes a protein similar to P-glycoprotein, known for multidrug resistance.
  • Understanding the function of mdr2 is essential for elucidating cellular transport mechanisms.

Purpose of the Study:

  • To investigate the function of the mdr2 protein.
  • To determine the role of mdr2 in phospholipid transport.

Main Methods:

  • Analysis of the phenotype of mice homozygous for mdr2 gene mutations.

Main Results:

  • Mice homozygous for mdr2 mutations exhibit a specific phenotype.
  • This phenotype is indicative of a disruption in phospholipid transport.

Conclusions:

  • The mdr2 protein is implicated in the process of phospholipid transport.
  • Further research into mdr2 function could reveal new insights into membrane transport and related diseases.

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