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Treatment of depression

T R Payk1

  • 1Westfälisches Zentrum für Psychiatrie der Ruhr-Universität, Bochum, Germany.

Journal of Geriatric Psychiatry and Neurology
|October 1, 1994
PubMed
Summary

Depression treatments have evolved from ancient plant extracts and therapies to modern pharmacotherapy. Current antidepressant drug development focuses on improving patient tolerance and therapeutic outcomes.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Ethnobotany

Background:

  • Depression is a prevalent psychiatric disorder with a long history of treatment approaches.
  • Traditional medicine utilized various plant extracts and psychotherapeutic interventions for mood disorders.

Observation:

  • Historical treatments included opium, belladonna, hashish, hyoscyamine, scopolamine, and hypericum oil.
  • 19th-century pharmacotherapy saw the introduction of bromides, codeine, chloral hydrate, paraldehyde, and barbiturates.
  • Modern antidepressant therapy began with imipramine in 1957, leading to approximately 40 marketed drugs.

Findings:

  • The evolution of depression treatment spans millennia, from ethnobotanical remedies to synthetic pharmaceuticals.
  • Significant advancements in pharmacotherapy occurred in the 19th and 20th centuries.

Implications:

  • Future antidepressant drug development should prioritize enhanced patient tolerance.
  • Understanding historical treatments provides context for contemporary psychiatric pharmacotherapy.

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