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Modulation of cytokine expression by hypericum extract

B Thiele1, I Brink, M Ploch

  • 1Medizinische Fakultät (Charité) der Humboldt Universität zu Berlin, Germany.

Journal of Geriatric Psychiatry and Neurology
|October 1, 1994
PubMed

The effect of hypericum extract LI 160 on the stimulated cytokine expression was investigated in vitro in a whole blood culture system. Blood samples were taken from five healthy volunteers and four depressive patients. The release of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) was measured quantitatively after an incubation time of 24 hours on microtiter plates. A massive suppression of the interleukin-6 release was found for PHA-stimulated hypericum extract. Possible relations to the antidepressive effects of hypericum extract are discussed.

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