[Antigenic specificity of influenza type A virus hemagglutinin by the method of radioimmunological quantitative...

The use of a test system o fa highly purified, antigenically homogeneus hemagglutinin of influenza A/MRC-11 virus and monospecific antiserum permitted to evaluate the potentials of competitive radioimmunoassay in model experiments investigating the antigenic characteristics and content of influenza A (H3N2) virus hemagglutinin. The method proved to be sufficiently specific to differentiate influenza virus strains by antigenic determinants of hemagglutinin, as well as highly sensitive, detecting very small (down to 1 ng) amounts of H3 hemagglutinin in a sample.