[Biological markers of osteoarthritis]

The degradation of proteoglycans, collagens and proteins in the articular cartilage matrix produces fragments which diffuse out of the tissue and into the joint fluid. These fragments subsequently appear in the blood circulation and are eventually eliminated by the liver or the kidney. Recent studies have shown that the joint fluid and blood levels of these biological markers of degradation can be used to monitor abnormal metabolic processes in cartilages. The joint fluid level of a cartilage-derived marker provides information about the metabolism of that molecule in that joint. In blood, levels of specific markers have been shown to be helpful in identifying systemic changes affecting the metabolism of matrix constituents in all or most cartilages in the body. Measurement of different biological markers in body fluids have proved useful in identifying increased catabolic activities in articular cartilage during the preradiological stages of osteoarthritis. These markers have great potential for monitoring disease activity, assessing disease progression, examining responses to drug therapy and evaluating long-term prognosis. In addition, markers should prove most useful in prospective studies at identifying early changes in cartilage metabolism in humans at high risk of developing post-traumatic osteoarthritis.