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Nimodipine

P C Whitfield1, J D Pickard

  • 1University Department of Neurosurgery, Addenbrooke's Hospital, Cambridge.

British Journal of Hospital Medicine
|November 13, 1994
PubMed
Summary
This summary is machine-generated.

Nimodipine, a calcium channel blocker, helps prevent and lessen brain damage after subarachnoid hemorrhage. This review covers its action, how it works, and when to use this important medication.

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Area of Science:

  • Pharmacology
  • Neurology
  • Critical Care Medicine

Background:

  • Subarachnoid hemorrhage (SAH) frequently leads to delayed cerebral ischemia (DCI).
  • DCI significantly increases morbidity and mortality in SAH patients.
  • Effective preventative strategies for DCI are crucial in neurocritical care.

Purpose of the Study:

  • To review the mechanism of action of nimodipine.
  • To discuss the pharmacology of nimodipine.
  • To outline the established indications for nimodipine use in SAH.

Main Methods:

  • Literature review of nimodipine's pharmacological properties.
  • Analysis of clinical studies on nimodipine's efficacy in SAH.
  • Synthesis of evidence regarding nimodipine's role in preventing DCI.

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Main Results:

  • Nimodipine acts as a lipophilic dihydropyridine calcium antagonist.
  • It selectively blocks L-type calcium channels in cerebral vasculature.
  • Clinical data support nimodipine's effectiveness in reducing DCI incidence and severity.

Conclusions:

  • Nimodipine is a key therapeutic agent for managing SAH.
  • Its mechanism involves selective cerebral vasodilation.
  • Appropriate use of nimodipine improves outcomes for SAH patients by mitigating DCI.