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Diltiazem hydrochloride
1Department of Cardiology, St Thomas' Hospital, London.
British Journal of Hospital Medicine
|October 1, 1994
Insights
Calcium-channel blockers, like diltiazem hydrochloride, are effective treatments introduced in 1963. Diltiazem is primarily used for angina, but also treats high blood pressure and irregular heart rhythms.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Calcium-channel blockers (CCBs) have been utilized since 1963.
- CCBs are recognized for their efficacy and favorable side effect profiles.
- Diltiazem hydrochloride is a notable CCB belonging to the benzothiazine class.
Purpose of the Study:
- To review the established applications of diltiazem hydrochloride.
- To highlight its primary role in managing angina pectoris.
- To discuss its secondary uses as an antihypertensive and antiarrhythmic agent.
Main Methods:
- Literature review of clinical studies and pharmacological data.
- Analysis of therapeutic outcomes and side effect profiles.
- Synthesis of information on diltiazem hydrochloride's mechanism of action and clinical utility.
Main Results:
- Diltiazem hydrochloride demonstrates significant effectiveness in treating angina.
- Its antihypertensive properties are well-documented.
- It serves as a viable option for managing cardiac arrhythmias.
Conclusions:
- Diltiazem hydrochloride remains a valuable therapeutic agent in cardiovascular medicine.
- Its broad spectrum of action makes it a versatile drug for multiple cardiac conditions.
- The established safety and efficacy support its continued use in clinical practice.
Abstract:
Since their introduction in 1963, calcium-channel blockers, with their effectiveness and lack of side effects, have become widely used. Diltiazem hydrochloride, a benzothiazine, has its major role in the treatment of angina and is also used as an antihypertensive and antiarrhythmic.