Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipoprotein modification: cellular mechanisms

A Chait1, J W Heinecke

  • 1Department of Medicine, University of Washington, Seattle.

Current Opinion in Lipidology
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet.

Nutrition & diabetes·2015
Same author

Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice.

Nutrition & diabetes·2014
Same author

Influence of serum proteins on conformation of prostate-specific antigen.

Journal of biomolecular structure & dynamics·2012
Same author

Chronic insulin therapy reduces adipose tissue macrophage content in LDL-receptor-deficient mice.

Diabetologia·2011
Same author

Quantitative structure-activity relationship studies of TIBO derivatives using support vector machines.

SAR and QSAR in environmental research·2010
Same author

The effect of essential oils from Thymus broussonetii Boiss on transmission of Toxoplasma gondii cysts in mice.

Parasitology research·2010
Same journal

Editorial introduction.

Current opinion in lipidology·2026
Same journal

Heterozygosity for pathogenic variants in familial chylomicronemia syndrome genes: from carrier state to complex trait.

Current opinion in lipidology·2026
Same journal

Premature atherosclerotic cardiovascular disease in the MENA region: economic impact, barriers to care, and policy recommendations for an escalating crisis.

Current opinion in lipidology·2026
Same journal

The role of metabolic profiling and dietary intervention in the early diagnosis and prevention of atherosclerosis.

Current opinion in lipidology·2026
Same journal

A JAK of two trades: beneficial or adverse effects of Janus kinase inhibition for plasma LDL-cholesterol and major adverse cardiovascular events in inflammatory bowel disease patients?

Current opinion in lipidology·2026
Same journal

Inflammation and atherosclerotic cardiovascular disease: where do we go from here?

Current opinion in lipidology·2026
See all related articles

Oxidatively damaged low-density lipoprotein (LDL) plays a key role in atherosclerosis development. This review covers LDL oxidation pathways, properties, and its implications in the disease process.

Area of Science:

  • Cardiovascular Science
  • Biochemistry
  • Cell Biology

Background:

  • Atherosclerosis is a complex disease involving lipid accumulation and inflammation in artery walls.
  • Oxidized low-density lipoprotein (LDL) is increasingly recognized as a critical factor in atherogenesis.
  • Understanding the mechanisms of LDL oxidation is crucial for developing preventative and therapeutic strategies.

Purpose of the Study:

  • To review the cellular pathways responsible for LDL oxidation in vitro.
  • To elucidate the biological properties and effects of oxidized LDL.
  • To discuss the implications of LDL oxidation for the pathogenesis of atherosclerosis.

Main Methods:

  • Literature review of cellular pathways involved in LDL oxidation.
  • Analysis of studies detailing the biological characteristics of oxidized LDL.

Related Experiment Videos

  • Synthesis of findings to connect LDL oxidation to atherosclerosis development.

    • Main Results:

    • Detailed description of in vitro cellular mechanisms leading to LDL oxidation.
    • Identification of key biological properties of oxidized LDL, including its pro-inflammatory and cytotoxic effects.
    • Established link between LDL oxidation processes and the progression of atherosclerotic lesions.

    Conclusions:

    • Cellular LDL oxidation pathways are fundamental to understanding atherogenesis.
    • Oxidized LDL possesses atherogenic properties that drive disease development.
    • Targeting LDL oxidation may offer a promising therapeutic avenue for atherosclerosis.