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Microbiological transformations--XXIX. Enantioselective hydrolysis of epoxides using microorganisms: a mechanistic
S Pedragosa-Moreau1, A Archelas, R Furstoss
1Groupe de Chimie Organique et Bioorganique, URA CNRS 1320 Faculté des Sciences de Luminy, Marseille, France.
Bioorganic & Medicinal Chemistry
|July 1, 1994
Abstract:
The regio- and stereochemistry of the hydrolysis of styrene oxide 1 by two fungi: Aspergillus niger and Beauveria sulfurescens, were studied using H2(18)O labelling experiments. Also, the kinetic parameters of these hydrolyses were determined. We conclude that the epoxide hydrolases of these two fungi operate via different mechanisms.