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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
11:10

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Polyclonal antibodies and catalysis

D B Stephens1, B H Wilmore, B L Iverson

  • 1Department of Chemistry and Biochemistry, University of Texas at Austin 78712.

Bioorganic & Medicinal Chemistry
|July 1, 1994
PubMed

Some recent results involving catalytic polyclonal antibodies are described. Polyclonal antibodies isolated directly from serum contain the complete distribution of different IgG antibodies elicited via immunization, so catalytic results obtained with polyclonal antibodies can be used to characterize the overall catalytic activity produced in an animal in response to a given hapten. This new window on catalytic antibodies should be especially useful for identifying general trends relating hapten structure to antibody catalytic activity, for monitoring the maturation of catalytic activity during immunization, and for studying the variability of catalytic activity elicited in different animals immunized with the same hapten. Furthermore, studying the catalytic activity of polyclonal antibodies in serum may aid in the development of novel immunization-based therapies.

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