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[Anaplastic Ki-1/CD30 positive lymphoma]
1Siklův patologicko-anatomický ústav LF UK, Plzen.
Ceskoslovenska Patologie
|December 1, 1994
Summary
Ki-1 (CD30) positive lymphoma, a large cell variant, is a distinct entity with unique cell features. Early lymph node sinus infiltration can mimic metastatic carcinoma or melanoma, posing diagnostic challenges.
Area of Science:
- Hematopathology
- Oncology
- Immunohistochemistry
Context:
- Ki-1 (CD30) positive lymphoma, large cell variant, presents unique diagnostic challenges.
- Initial presentation often involves lymph node sinus infiltration.
- Distinguishing this lymphoma from metastatic carcinoma or melanoma can be difficult.
Purpose:
- To describe the distinct histopathological, immunophenotypic, and karyotypic features of Ki-1 (CD30) positive large cell lymphoma.
- To highlight the early diagnostic challenges posed by sinus infiltration.
- To present a series of six cases illustrating this rare entity.
Summary:
- Ki-1 (CD30) positive lymphoma in its large cell variant is a distinct histopathological entity.
- Characteristic morphology, immunophenotype, and karyotype define this lymphoma.
- Early lymph node infiltration can mimic other malignancies, necessitating careful evaluation.
Impact:
- Improved recognition of Ki-1 (CD30) positive large cell lymphoma.
- Enhanced diagnostic accuracy in differentiating from metastatic tumors.
- Better understanding of the early clinical and pathological presentation.