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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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KK mouse

¹Pharmaceutical Research Laboratories II, Takeda Chemical Ind., Ltd., Osaka, Japan.

Diabetes Research and Clinical Practice

|October 1, 1994

Summary

This summary is machine-generated.

The KK mouse model exhibits glucose intolerance and insulin resistance. Obesity exacerbates this, leading to hyperglycemia and glucosuria, making it valuable for studying obesity-associated diabetes.

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Area of Science:

Metabolic research
Animal models of diabetes

Background:

The KK mouse strain naturally displays impaired glucose tolerance and insulin resistance.
Obesity can progress this pre-diabetic state to overt diabetes in KK mice.

Purpose of the Study:

To highlight the utility of the KK mouse as a model for obesity-associated diabetes.
To describe the progression from chemical diabetes to overt diabetes in this model.

Main Methods:

Utilizing the KK mouse strain.
Inducing obesity through aging and dietary interventions.

Main Results:

KK mice develop hyperglycemia and glucosuria when obese.
The progression from insulin resistance to overt diabetes is observed.

Conclusions:

The KK mouse is a suitable model for studying the mechanisms of obesity-induced diabetes.
This model allows for investigation into the transition to a hyperglycemic and glucosuric state.