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A multicentre study: Staphylococcus and Enterococcus susceptibility to antibiotics

A Turano1, G Ravizzola, L Peroni

  • 1Institute of Microbiology, University of Brescia, Italy.

European Journal of Epidemiology
|October 1, 1994
PubMed
Summary
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This multicentre study assessed antibiotic susceptibility in Gram-positive cocci, finding oxacillin-resistant strains showed frequent multidrug resistance. Vancomycin and teicoplanin demonstrated excellent efficacy against staphylococci and enterococci.

Area of Science:

  • Clinical microbiology
  • Infectious diseases
  • Antimicrobial resistance

Background:

  • Gram-positive cocci, including Staphylococcus aureus, coagulase-negative staphylococci, and enterococci, are significant causes of clinical infections.
  • Monitoring antimicrobial susceptibility patterns is crucial for effective treatment strategies.

Purpose of the Study:

  • To evaluate the in vitro susceptibility of Gram-positive cocci isolated from clinical samples across multiple Italian centers.
  • To identify resistance trends and assess the efficacy of various antibiotics against common Gram-positive pathogens.

Main Methods:

  • A multicentre study involving six Italian centers.
  • Antimicrobial susceptibility testing was performed on 4,544 Staphylococcus aureus, 4,381 coagulase-negative staphylococci, and 2,478 enterococci strains.

Related Experiment Videos

  • A broad panel of 21 antibiotics was tested, including penicillins, cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, macrolides, and glycopeptides.

    • Main Results:

    • Oxacillin-susceptible staphylococci exhibited broad susceptibility, while oxacillin-resistant strains displayed frequent multidrug resistance.
    • Coagulase-negative staphylococci showed higher resistance to oxacillin, cotrimoxazole, and chloramphenicol compared to Staphylococcus aureus.
    • Enterococci were generally susceptible to penicillins and imipenem, with moderate susceptibility to ciprofloxacin. High-level aminoglycoside resistance was observed in 70-79% of strains.
    • Vancomycin and teicoplanin demonstrated excellent activity against both staphylococci and enterococci.

    Conclusions:

    • Significant antimicrobial resistance exists among Gram-positive cocci in Italy, particularly in oxacillin-resistant staphylococci.
    • Vancomycin and teicoplanin remain highly effective agents for treating infections caused by these pathogens.
    • Continuous surveillance of antimicrobial resistance patterns is essential for guiding clinical practice and public health interventions.