Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoglycemic depression of RES function

B J Buchanan, J P Filkins

    The American Journal of Physiology
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Low blood glucose levels significantly impair the reticuloendothelial system (RES) clearance of carbon and endotoxin in rats. This suggests that hypoglycemia may worsen conditions like endotoxin shock by hindering the body

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pseudoephedrine and air travel-associated ear pain in children.

    Archives of pediatrics & adolescent medicine·1999
    Same author

    Glucocorticoid regulation of hepatic TNF production following cecal ligation and puncture sepsis.

    Shock (Augusta, Ga.)·1997
    Same author

    Molsidomine increases endotoxic survival and decreases cytokine production.

    Shock (Augusta, Ga.)·1997
    Same author

    Partial hepatectomy reduces the endotoxin-induced peak circulating level of tumor necrosis factor in rats.

    Shock (Augusta, Ga.)·1996
    Same author

    Bronchoalveolar lavage fluid endotoxin elevation in human single lung transplant recipients during rejection.

    Transplant immunology·1995
    Same author

    Glucose transporters (GLUT1, 2, & 4) in fat, muscle and liver in a rat model of endotoxic shock.

    Biochemical and biophysical research communications·1994
    Same journal

    Blood coagulation in fish.

    The American journal of physiology·2011
    Same journal

    Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

    The American journal of physiology·2010
    Same journal

    The inactivation of placental toxin by human serum.

    The American journal of physiology·2010
    Same journal

    Adrenal function following ovariectomy in the rat.

    The American journal of physiology·2010
    Same journal

    Capillary permeability; perfusion of frog and guinea pig hind limbs.

    The American journal of physiology·2010
    Same journal

    Evaluation of protective measures against sunburn.

    The American journal of physiology·2010
    See all related articles

    Area of Science:

    • Immunology
    • Endocrinology
    • Physiology

    Background:

    • The reticuloendothelial system (RES) is crucial for clearing intravascular pathogens and debris.
    • Blood glucose levels can influence various physiological processes, but their impact on RES function is not fully understood.

    Purpose of the Study:

    • To investigate the relationship between blood glucose levels and the clearance capacity of the RES.
    • To determine how insulin-induced hypoglycemia affects the RES's ability to remove colloidal carbon and endotoxin.

    Main Methods:

    • Rats were treated with saline or insulin to induce varying blood glucose levels.
    • Intravascular clearance rates of colloidal carbon were measured by monitoring blood levels over time.
    • The effect of hypoglycemia on endotoxin removal was assessed using a lethality bioassay in lead-sensitized rats.

    Related Experiment Videos

    Main Results:

    • A significant negative correlation was observed between blood glucose levels and carbon clearance half-time in both saline- and insulin-treated rats.
    • Insulin-induced hypoglycemia markedly depressed RES carbon clearance, with the most significant impairment occurring at blood glucose levels below 30 mg/dl.
    • Hypoglycemia severely impaired the intravascular removal of endotoxin, leading to increased lethality in endotoxin-challenged rats.

    Conclusions:

    • Blood glucose levels play a significant role in modulating the phagocytic function of the RES.
    • Hypoglycemia, particularly that associated with endotoxin shock, may exacerbate the shock state by impairing crucial RES host defense and clearance functions.