Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-responsiveness to antimicrobial therapy

R D Lele

    The Journal of the Association of Physicians of India
    |February 1, 1994
    PubMed
    Summary
    This summary is machine-generated.

    Clinicians face challenges with non-response to drugs, where expected benefits aren't seen. This review explores diverse causes, including patient factors, disease characteristics, and drug properties, impacting treatment outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transiting from pathy-based to people-centered holistic healthcare.

    Journal of Ayurveda and integrative medicine·2020
    Same author

    Psychological Insulin Resistance in Patients with Type 2 Diabetes Mellitus.

    The Journal of the Association of Physicians of India·2016
    Same author

    Journal of Nuclear Cardiology Nuclear Cardiology News Update.

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2016
    Same author

    Tc 99m Sestamibi Scanning in Multiple Myeloma--a New look with SPECT-CT.

    The Journal of the Association of Physicians of India·2015
    Same author

    How to ascertain drug related deaths during clinical trials ?

    The Journal of the Association of Physicians of India·2014
    Same author

    Ancient Indian insights and modern discoveries in nutrition, exercise and weight control.

    The Journal of the Association of Physicians of India·2012

    Area of Science:

    • Clinical Pharmacology
    • Pharmacology
    • Internal Medicine

    Background:

    • Drug non-response is a significant clinical challenge, leading to suboptimal therapeutic outcomes.
    • Understanding the multifactorial causes of treatment failure is crucial for effective patient management.

    Purpose of the Study:

    • To comprehensively review the diverse causes of drug non-responsiveness encountered in clinical practice.
    • To highlight the interplay between host, parasite, and drug-related factors in treatment outcomes.

    Main Methods:

    • Literature review and synthesis of established knowledge in clinical pharmacology.
    • Case examples from common diseases to illustrate principles of drug non-response.

    Main Results:

    Related Experiment Videos

  • Non-response can stem from diagnostic inaccuracies, disease subtypes, or microbial resistance.
  • Factors include inappropriate drug dosage, administration, patient compliance, and altered pharmacokinetics.
  • Host-related factors, such as receptor changes and compensatory mechanisms, also contribute significantly.

    • Conclusions:

    • Drug non-response is complex, influenced by a combination of patient, pathogen, and drug-specific elements.
    • The principles discussed are broadly applicable across various diseases and therapeutic interventions.
    • Addressing drug non-response requires a holistic approach considering all contributing factors.