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Botulinum toxin A in blepharospasm and hemifacial spasm
M Behari1, K K Singh, S Seshadri
1Department of Neurology, All India Institute of Medical Sciences, New Delhi.
The Journal of the Association of Physicians of India
|March 1, 1994
Summary
Botulinum toxin A effectively treats blepharospasm and hemifacial spasm in India. Most patients showed over 70% improvement, with effects lasting nearly 17 weeks and minimal side effects.
Area of Science:
- Neurology
- Ophthalmology
- Dermatology
Background:
- Blepharospasm and hemifacial spasm are debilitating conditions.
- Botulinum toxin A is a recognized treatment for focal dystonias.
Purpose of the Study:
- To document the initial Indian experience with botulinum toxin A for blepharospasm and hemifacial spasm.
- To evaluate the efficacy, duration of response, and safety of botulinum toxin A in these conditions.
Main Methods:
- Sixteen patients (7 essential blepharospasm, 5 Meige syndrome, 4 hemifacial spasm) received botulinum toxin A injections.
- Treatment outcomes and side effects were monitored.
Main Results:
- All patients experienced symptom relief within 48 hours, with a mean duration of 16.65 weeks.
- 85% of injections resulted in over 70% improvement.
- Blepharoptosis was the most common, mild, and transient side effect.
Conclusions:
- Botulinum toxin A is a safe and effective treatment for blepharospasm and hemifacial spasm in the Indian population.
- The treatment offers significant improvement with a good duration of effect and a favorable safety profile.