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Laryngeal leishmaniasis

A Grant1, P D Spraggs, H R Grant

  • 1Hospital for Tropical Diseases, London.

The Journal of Laryngology and Otology
|December 1, 1994
PubMed
Summary
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A rare case of laryngeal leishmaniasis, a persistent hoarseness diagnosis, was identified in the UK after a 16-year incubation. Effective treatment involved liposomal amphotericin, highlighting a rare Eastern hemisphere manifestation.

Area of Science:

  • Medical Parasitology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Leishmaniasis is a parasitic disease typically affecting the skin or mucous membranes.
  • Mucosal leishmaniasis is uncommon in the Eastern Hemisphere.
  • Laryngeal leishmaniasis is a rare manifestation with limited reported cases.

Observation:

  • A patient presented with persistent hoarseness, a symptom initially misdiagnosed.
  • Diagnostic investigations revealed laryngeal leishmaniasis with an incubation period of at least 16 years.
  • The patient had a history of potential exposure in Southern Europe.

Findings:

  • This represents the first reported case of laryngeal leishmaniasis in the UK.
  • The chronic course and presentation mimicked malignancy, causing diagnostic challenges.

Related Experiment Videos

  • Aminosidine treatment was ineffective, but liposomal amphotericin achieved a positive clinical response.

    • Implications:

    • This case expands the known geographical distribution of mucosal leishmaniasis.
    • It underscores the importance of considering leishmaniasis in the differential diagnosis of chronic hoarseness, even in non-endemic regions.
    • Successful treatment with liposomal amphotericin offers a viable therapeutic option for this rare condition.