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[Pathogenetic mechanisms responsible for producing a secondary immunodeficiency state]
1Clinica Malattie Infettive, Università di Firenze.
Journal of Chemotherapy (Florence, Italy)
|August 1, 1994
Summary
Immune response abnormalities are common in aging, diseases like diabetes and cancer, and after treatments such as surgery or radiation. These conditions impair both antibody and cell-mediated immunity, affecting overall health.
Area of Science:
- Immunology
- Pathophysiology
- Gerontology
Background:
- Immune response abnormalities are frequently observed in various clinical settings.
- These include aging, chronic diseases, surgical stress, burns, and immunosuppressive therapies.
Purpose of the Study:
- To review the multifaceted causes and consequences of immune response abnormalities.
- To highlight the impact on both humoral and cell-mediated immunity.
Main Methods:
- Literature review of conditions affecting immune function.
- Analysis of immune response changes in aging, disease, and treatment contexts.
Main Results:
- Aging impairs antibody synthesis and cell-mediated immunity (thymus involution, altered T-cell ratios).
- Diseases (diabetes, renal failure, neoplasias) and malnutrition further compromise immune functions.
- Surgical stress, burns, and immunosuppressive therapies significantly alter immune responses, including antibody production and cellular activities.
Conclusions:
- A wide range of factors, from aging to specific diseases and treatments, can lead to significant immune dysfunction.
- Understanding these abnormalities is crucial for managing patient outcomes in diverse clinical scenarios.