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Related Experiment Videos

Intraocular effects of pimaricin

A C Ellison, E Newmark

    Annals of Ophthalmology
    |August 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Intraocular pimaricin at 250 mug is safe and effective for treating fungal eye infections in rabbits, maintaining therapeutic levels for over 24 hours. Higher doses caused irreversible damage in infected eyes.

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    Intravenous effects of pimaricin on mycotic endophthalmitis.

    Annals of ophthalmology·1979

    Area of Science:

    • Ophthalmology
    • Mycology
    • Pharmacology

    Background:

    • Fungal endophthalmitis poses a significant threat to vision.
    • Pimaricin is an antifungal agent with potential ocular applications.

    Purpose of the Study:

    • To evaluate the safety and efficacy of intraocular pimaricin in rabbits.
    • To determine optimal dosage for treating fungal endophthalmitis.

    Main Methods:

    • Pigmented rabbits received intraocular injections of pimaricin (250-1,000 mug).
    • Pharmacokinetic studies measured drug levels in ocular tissues.
    • Infection models with Aspergillus fumigatus were used to assess therapeutic effects and toxicity.

    Main Results:

    • 250 mug of intraocular pimaricin was well-tolerated in normal and infected eyes.

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  • Therapeutic ocular levels were maintained for over 24 hours.
  • Doses exceeding 250 mug led to irreversible ocular damage in infected eyes.

    • Conclusions:

    • A 250 mug intraocular dose of pimaricin may preserve vision in cases of fungal endophthalmitis.
    • Careful dosage is crucial to avoid ocular toxicity in infected eyes.