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[Hemodynamics during hypervolemic hemodilution (HH) technique]

K Kikuchi1, A Konishi, M Terashima

  • 1Department of Anesthesia, New Tokyo Hospital, Matsudo.

Masui. the Japanese Journal of Anesthesiology
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

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Hypervolemic hemodilution (HH) effectively avoids blood transfusions by increasing blood volume. Vasodilating therapy, like nitroglycerin, helps manage increased cardiovascular pressures during this procedure.

Area of Science:

  • Cardiovascular Physiology
  • Hemodynamics
  • Anesthesiology

Context:

  • Hypervolemic hemodilution (HH) is an alternative to blood transfusion.
  • Managing hemodynamic changes during HH is crucial.
  • Adult mongrel dogs were used as a model.

Purpose:

  • To investigate hemodynamic responses during HH.
  • To evaluate the effect of vasodilating therapy on hemodynamics during HH.

Summary:

  • HH involves fluid loading (HES and Ringer's lactate) without blood withdrawal.
  • Nitroglycerin administration (1 µg/kg/min) in group N reduced central venous pressure (CVP), pulmonary artery pressure (PAP), and pulmonary capillary wedge pressure (PCWP) compared to the control group (C).
  • Cardiac output (CO) increased more in group N than in group C, while hematocrit (Hct) decreased to 30% with normal oxygenation and pH.

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Impact:

  • HH is a viable technique to avoid blood transfusions.
  • Vasodilating therapy effectively mitigates excessive volume loading and associated increases in CVP and PCWP during HH.
  • This study provides insights into managing hemodynamics during fluid resuscitation strategies.