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Abstract:
Thirty-six patients with coliform meningitis in the 15-year period 1960-1974 are reported. Only 9 patients survived unscathed though the other 5 survivors were not seriously affected. During the septicaemic phase of the illness the cerebrospinal fluid (CSF), though positive on culture, may be otherwise normal. Meningitis can ensue even when the patient is receiving antibiotics to which the organism is sensitive and the possible disadvantages of using a nondiffusible antibiotic must be appreciated. The CSF in Esch. coli meningitis can be persistently haemorrhagic which may cause difficulties in the initial diagnosis. It must be emphasized that infective illness in the newborn is often nonspecific in its presentation and that repeated bacteriological investigations are essential in neonates who are unwell.
Insights
Coliform meningitis, particularly in newborns, presents diagnostic challenges and can occur despite antibiotic treatment. Early and repeated bacterial testing is crucial for timely intervention and improved outcomes in sick neonates.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neonatology
Background:
- Coliform meningitis is a serious infection affecting infants.
- The presentation of neonatal infections can be nonspecific, complicating diagnosis.
Purpose of the Study:
- To report on a series of coliform meningitis cases.
- To highlight diagnostic challenges and treatment considerations.
Main Methods:
- Retrospective review of 36 patients with coliform meningitis from 1960-1974.
- Analysis of clinical presentation, cerebrospinal fluid (CSF) findings, and outcomes.
Main Results:
- Only 9 of 36 patients survived without serious sequelae.
- CSF may appear normal despite positive cultures during the septicemic phase.
- Persistent hemorrhagic CSF can impede initial diagnosis.
- Meningitis can develop even with sensitive antibiotic therapy, especially with nondiffusible agents.
Conclusions:
- Coliform meningitis poses significant mortality and morbidity risks.
- Nonspecific presentation in neonates necessitates repeated bacteriological investigations.
- Careful antibiotic selection is vital, considering drug diffusion into the CSF.