Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glomerular changes in dengue hemorrhagic fever

V Boonpucknavig, N Bhamarapravati, S Boonpucknavig

    Archives of Pathology & Laboratory Medicine
    |April 1, 1976
    PubMed
    Summary

    Dengue hemorrhagic fever can cause kidney damage. Immune complexes and dense particles in the glomeruli, detected via kidney biopsies, indicate potential renal impairment in patients with dengue.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Enhanced peritubular capillary flow and renal function can be accomplished in normoalbuminuric type 2 diabetic nephropathy.

    Renal failure·2011
    Same author

    Pathology of Thai haemorrhagic fever: an autopsy study.

    Bulletin of the World Health Organization·2010
    Same author

    Pathogenetic studies on Thai haemorrhagic fever: immunofluorescent localization of dengue virus in human tissue.

    Bulletin of the World Health Organization·2010
    Same author

    Bone-marrow studies in Thai haemorrhagic fever.

    Bulletin of the World Health Organization·2010
    Same author

    Renal microvascular and tubular injuries in type II diabetic nephropathy.

    Kidney international·2008
    Same author

    Diagnostic markers for early detection of diabetic retinopathy and nephropathy.

    Clinical nephrology·2008

    Area of Science:

    • Nephrology
    • Infectious Diseases
    • Immunology

    Background:

    • Dengue hemorrhagic fever (DHF) is a severe mosquito-borne viral illness.
    • Renal impairment is a known complication of DHF, but its pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate the renal pathology in patients with dengue hemorrhagic fever and clinical signs of kidney impairment.
    • To identify potential immune mechanisms contributing to DHF-associated kidney injury.

    Main Methods:

    • Percutaneous kidney biopsies were performed on 20 patients with DHF and renal impairment.
    • Immunofluorescence microscopy was used to detect immune deposits (IgG, IgM, C3) in glomeruli.
    • Electron microscopy examined glomerular ultrastructure and identified specific particles.

    Main Results:

    • Immune complex deposition (IgG, IgM, C3) in glomeruli was observed in 10 out of 20 patients, primarily during the second week of fever.
    • Electron microscopy revealed focal glomerular basement membrane thickening and mesangial cell hypertrophy where immune complexes were present.
    • Dense, spherical particles (40-50 nm) were identified in 12 cases, often associated with monocyte infiltration into glomeruli.

    Conclusions:

    • Immune complex deposition and associated ultrastructural changes in the glomeruli are implicated in the renal impairment seen in dengue hemorrhagic fever.
    • The presence of dense particles, potentially viral or immune-related, warrants further investigation into their role in DHF nephropathy.

    Related Experiment Videos