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Preference for high- versus low-potency marijuana

L D Chait1, K A Burke

  • 1Department of Psychiatry, MC3077, Pritzker School of Medicine, University of Chicago, IL 60637.

Pharmacology, Biochemistry, and Behavior
|November 1, 1994
PubMed
Summary
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Humans prefer higher potency marijuana, indicating that delta-9-tetrahydrocannabinol (THC) content influences marijuana

Area of Science:

  • Addiction research
  • Human pharmacology
  • Cannabis studies

Background:

  • Many drugs of abuse show dose-preference in humans and animals.
  • Marijuana's reinforcing effects and abuse potential are key research areas.

Purpose of the Study:

  • To investigate if humans prefer higher potency marijuana during smoking.
  • To determine the relationship between delta-9-tetrahydrocannabinol (THC) content and marijuana choice.

Main Methods:

  • Twelve regular marijuana smokers participated in choice trials.
  • Subjects sampled marijuana with 0.63% and 1.95% THC before choosing.
  • Physiological and subjective effects were monitored during sampling.

Main Results:

Related Experiment Videos

  • High-potency marijuana (1.95% THC) caused greater heart rate increase and subjective effects.
  • Subjects significantly preferred the high-potency marijuana (21 out of 24 choices).

    • Conclusions:

    • Human preference for marijuana is positively related to THC content.
    • Higher THC levels may increase marijuana's reinforcing effects and abuse liability.