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Tolerance development to butorphanol: comparison with morphine

Y Z Feng1, Y T Tseng, S P Jaw

  • 1Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216.

Pharmacology, Biochemistry, and Behavior
|November 1, 1994
PubMed
Summary
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Rats developed tolerance to morphine faster than butorphanol. While both drugs showed decreased antinociceptive response with increased infusion, morphine tolerance was more pronounced than butorphanol tolerance.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Pain Research

Background:

  • Opioid analgesics like butorphanol and morphine are used for pain management.
  • Understanding the development of tolerance to these drugs is crucial for effective clinical use.
  • Comparing tolerance development between different opioids can inform treatment strategies.

Purpose of the Study:

  • To compare the time course, dose-response, and tolerance development to butorphanol and morphine.
  • To evaluate the degree of tolerance induced by continuous intracerebroventricular infusion of these opioids in rats.

Main Methods:

  • Rats were infused intracerebroventricularly (ICV) with varying doses of butorphanol or morphine, or saline, for 1-3 days.
  • Tail-flick responses were measured before, during, and after drug infusion.

Related Experiment Videos

  • Antinociceptive effects were assessed using tail-flick and acetic acid writhing tests.

    • Main Results:

    • Morphine induced faster tolerance development compared to butorphanol.
    • A significant decrease in antinociceptive response was observed post-infusion, correlating negatively with infused drug dose.
    • Dose-response curves shifted rightward, indicating tolerance, with greater shifts for morphine than butorphanol in tail-flick tests.

    Conclusions:

    • Greater tolerance develops to morphine than to butorphanol, although butorphanol tolerance is substantial.
    • Pain assay methodology influences the estimation of opioid tolerance, highlighting the need for careful assay selection.