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Related Experiment Videos

Crosstolerance between butorphanol and morphine in rats

Y Z Feng1, M Narita, Y T Tseng

  • 1Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216.

Pharmacology, Biochemistry, and Behavior
|November 1, 1994
PubMed
Summary

Chronic butorphanol administration in rats led to cross-tolerance to morphine and U-50,488, indicating desensitization of central kappa and mu receptors. This suggests potential implications for pain management strategies.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Pain Research

Background:

  • Opioid analgesics like morphine and U-50,488 are crucial for pain management.
  • Understanding receptor interactions and tolerance is vital for optimizing pain relief and minimizing adverse effects.

Purpose of the Study:

  • To investigate the antinociceptive effects of morphine and U-50,488 following continuous butorphanol administration.
  • To explore the development of cross-tolerance between butorphanol, morphine, and U-50,488 in rats.

Main Methods:

  • Rats received continuous intracerebroventricular (ICV) infusion of butorphanol via osmotic minipumps for 3 days.
  • Following infusion, rats were challenged with varying doses of morphine or U-50,488.
  • Antinociceptive effects were assessed using tail-flick and acetic acid writhing tests.

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Main Results:

  • Butorphanol-infused rats exhibited cross-tolerance to morphine's antinociceptive effects.
  • Continuous ICV morphine infusion led to the development of cross-tolerance to butorphanol.
  • Continuous butorphanol infusion caused a significant rightward shift in the U-50,488 antinociceptive dose-response curve.

Conclusions:

  • Antinociceptive cross-tolerance exists between butorphanol and morphine.
  • Continuous butorphanol administration induced cross-tolerance to U-50,488.
  • Chronic high-dose butorphanol desensitizes central kappa and mu receptors involved in antinociception in rats.