Adrenal gland enhancement at MR imaging with Mn-DPDP

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D G Mitchell1, E K Outwater, T Matteucci

  • 1Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA.

Radiology
|March 1, 1995
PubMed
Abstract

Insights

Manganese (II) N,N

Area of Science:

  • Radiology
  • Medical Imaging
  • Contrast Agents

Background:

  • Adrenal gland imaging is crucial for diagnosing various conditions.
  • Enhancement patterns can aid in differentiating adrenal lesions.
  • Novel contrast agents are continuously being developed for improved MRI.

Purpose of the Study:

  • To evaluate the enhancement characteristics of adrenal glands using manganese (II) N,N' dipyridoxylethylenediamine-N,N'-diacetate 5,5'bis(phosphate) (Mn-DPDP) in MRI.
  • To assess Mn-DPDP as a potential contrast agent for adrenal imaging.

Main Methods:

  • 13 consecutive patients underwent MRI at 1.5 T before and after intravenous Mn-DPDP administration.
  • Fat-suppressed, T1-weighted spin-echo images were acquired.
  • Region-of-interest measurements, normalized to spleen, were used for analysis.

Main Results:

  • All 26 depicted adrenal glands showed enhancement after Mn-DPDP administration.
  • Mean adrenal enhancement (38%) was comparable to other organs like liver and renal cortex.
  • Adrenal adenomas enhanced significantly (>40%), while metastases did not.

Conclusions:

  • Functioning adrenal tissue, including glands and some adenomas, demonstrates enhancement with Mn-DPDP.
  • Mn-DPDP shows potential as an MRI contrast agent for evaluating adrenal tissue.

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