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Diffuse pleural thickening: percutaneous CT-guided cutting needle biopsy

E M Scott1, T J Marshall, C D Flower

  • 1Department of Radiology, Addenbrooke's Hospital, Cambridge, England.

Radiology
|March 1, 1995
PubMed
Summary

Computed tomography (CT)-guided cutting needle biopsy of diffuse pleural thickening yields accurate diagnoses. Combining biopsy results with CT imaging improves diagnostic accuracy, making it a valuable first-line investigation.

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Area of Science:

  • Medical Imaging
  • Thoracic Surgery
  • Pathology

Background:

  • Diffuse pleural thickening is a common finding with diverse etiologies.
  • Accurate diagnosis is crucial for appropriate patient management.
  • Percutaneous biopsy is a key diagnostic tool.

Purpose of the Study:

  • To evaluate the diagnostic yield of CT-guided percutaneous cutting needle biopsy for diffuse pleural thickening.
  • To determine the accuracy of this method in differentiating malignant from benign pleural disease.

Main Methods:

  • Retrospective analysis of 45 CT-guided percutaneous biopsies in 42 adult patients with diffuse pleural disease.
  • Use of an 18-gauge cutting needle and a spring-operated biopsy instrument.
  • Assessment of diagnostic yield and accuracy in differentiating benign from malignant conditions.

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Main Results:

  • Histologic diagnosis was obtained in 42 of 45 biopsies (93%).
  • Correct histologic diagnosis was achieved in 39 of 42 specimens (93%).
  • Combined CT and biopsy findings achieved 100% sensitivity and 100% negative predictive value for differentiating malignant from benign disease.

Conclusions:

  • CT-guided percutaneous cutting needle biopsy is an effective method for diagnosing diffuse pleural thickening.
  • Integration of CT imaging findings with biopsy results enhances diagnostic performance.
  • This combined approach serves as a valuable first-line investigation for diffuse pleural abnormalities.