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[Introduction to the process of oncogenesis: cancers are somatic genetic diseases]

N Janin1

  • 1Service de Médecine B, institut Gustave-Roussy, Villejuif, France.

La Revue De Medecine Interne
|January 1, 1994
PubMed

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Such genes that act...