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Thyroid disorders in Korean patients with systemic lupus erythematosus
1Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.
Scandinavian Journal of Rheumatology
|January 1, 1995
Summary
Thyroid disorders, including Hashimoto's thyroiditis, are common in patients with systemic lupus erythematosus (SLE). Antithyroid autoantibodies can help predict the development of Hashimoto's thyroiditis in SLE patients.
Area of Science:
- Rheumatology
- Endocrinology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is an autoimmune condition with known associations with thyroid disorders.
- The exact prevalence and specific types of thyroid dysfunction in SLE patients remain debated.
Purpose of the Study:
- To determine the prevalence of thyroid disorders in Korean patients diagnosed with SLE.
- To investigate the association between SLE and specific thyroid conditions, including autoimmune thyroid diseases.
Main Methods:
- Evaluation of thyroid function and diseases in a cohort of 63 Korean patients with SLE.
- Assessment of antithyroid autoantibody (antimicrosomal and antithyroglobulin) prevalence.
Main Results:
- Hashimoto's thyroiditis (9.5%) and euthyroid sick syndrome (14.3%) were more prevalent than Graves' disease (4.8%) in SLE patients.
- Antithyroid autoantibodies were present in 27.0% of SLE patients, primarily associated with Hashimoto's thyroiditis.
- High titers of antithyroid autoantibodies were predominantly found in patients with Hashimoto's thyroiditis.
Conclusions:
- Thyroid diseases are frequently observed in patients with SLE.
- Autoimmune thyroid diseases, particularly Hashimoto's thyroiditis, can be a manifestation of SLE.
- Antithyroid autoantibodies may serve as predictive markers for identifying Hashimoto's thyroiditis in SLE patients.