[Lymphocytic interstitial pneumonia as a variant of a precancerous lung lesion]

The paper reports a rare case of 26-year-old female with diffuse infiltrative lesions in both lungs. Blood tests revealed hypergammaglobulinemia and fast ESR. Lung biopsies exhibited diffuse lymphoid infiltration with fibroatelectasis regions. Cytological and immunophenotypic studies of the lavage showed polyclonal composition of the cell population and prevalence of mature lymphocytes. The diagnosis was made of lymphocytic interstitial pneumonia (LIP). No progression of the condition was observed. In view of expected malignant transformation the case was followed up. Benign characteristics of lymphocytic infiltration, no negative shifts within 5 years allow avoiding active immunodepressive treatment in this stage of the disease which belongs to diffuse forms of pseudolymphoma and is considered to be a prelymphomatosis status.