Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary surfactant therapy

F R Poulain1, J A Clements

  • 1Department of Pediatrics, University of California, San Francisco, School of Medicine.

The Western Journal of Medicine
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Constraints to counting bioluminescence producing cells by a commonly used transgene promoter and its implications for experimental design.

Scientific reports·2019
Same author

The Microwell-mesh: A high-throughput 3D prostate cancer spheroid and drug-testing platform.

Scientific reports·2018
Same author

A humanised tissue-engineered bone model allows species-specific breast cancer-related bone metastasis in vivo.

Journal of tissue engineering and regenerative medicine·2017
Same author

Determining Protease Substrates Within a Complex Protein Background Using the PROtein TOpography and Migration Analysis Platform (PROTOMAP).

Methods in molecular biology (Clifton, N.J.)·2017
Same author

Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.

British journal of cancer·2015
Same author

The kallikrein-related peptidase family: Dysregulation and functions during cancer progression.

Biochimie·2015
Same journal

Does daily use of sunscreen or beta-carotene supplements prevent skin cancer in healthy adults?

The Western journal of medicine·2008
Same journal

[Not Available].

The Western journal of medicine·2008
Same journal

[Not Available].

The Western journal of medicine·2008
Same journal

[Not Available].

The Western journal of medicine·2008
Same journal

[Not Available].

The Western journal of medicine·2008
Same journal

[Not Available].

The Western journal of medicine·2008
See all related articles

Surfactant replacement therapy effectively treats neonatal hyaline membrane disease, reducing mortality and air leak. Further research is needed for adult respiratory distress syndrome and other lung conditions.

Area of Science:

  • Neonatology
  • Pulmonology
  • Critical Care Medicine

Background:

  • Surfactant replacement therapy is a cornerstone in neonatal intensive care.
  • Hyaline membrane disease (HMD) remains a significant cause of respiratory distress in premature infants.
  • Exogenous surfactant administration has demonstrated clinical benefits.

Purpose of the Study:

  • To review the efficacy of surfactant replacement therapy in neonates with HMD.
  • To explore the potential of surfactant therapy in adult respiratory distress syndrome (ARDS).
  • To identify areas for future research in surfactant therapy for various lung diseases.

Main Methods:

  • Systematic review of clinical trials involving natural and synthetic surfactant preparations.
  • Analysis of data on mortality, air leak, and bronchopulmonary dysplasia in neonates.

Related Experiment Videos

  • Evaluation of preliminary findings from ARDS patient studies.

    • Main Results:

    • Early surfactant treatment significantly reduces mortality and air leak in neonates with HMD.
    • Surfactant therapy did not substantially decrease the incidence of bronchopulmonary dysplasia.
    • Promising but limited data exist for surfactant use in ARDS.

    Conclusions:

    • Surfactant replacement therapy is a vital intervention for neonatal HMD.
    • Current evidence suggests a need for optimized surfactant administration strategies.
    • Further investigation is warranted for surfactant's role in ARDS and other pulmonary conditions.