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Hypercoagulability and the hypercoagulability syndromes

B A Perler1

  • 1Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287.

AJR. American Journal of Roentgenology
|March 1, 1995
PubMed
Summary

Hypercoagulability, an increased tendency for blood clotting, can cause arterial and venous thrombosis. Recent advances have improved diagnosis and treatment of these disorders, particularly for interventional radiologists.

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Area of Science:

  • Hematology
  • Vascular Medicine
  • Interventional Radiology

Background:

  • Hypercoagulability involves excessive platelet/fibrin deposition, leading to thrombosis.
  • Disorders are classified as primary (coagulation/fibrinolytic protein abnormalities) or secondary (broader, less defined molecular basis).
  • Recognized for over a century, with recent improvements in diagnostics and treatments.

Purpose of the Study:

  • To review hypercoagulability syndromes relevant to interventional radiologists.
  • To describe clinical presentation, diagnosis, and treatment strategies.
  • To highlight hypercoagulability as a cause of post-procedural thrombosis.

Main Methods:

  • Review of existing literature on hypercoagulability disorders.
  • Classification of primary and secondary hypercoagulability states.
  • Focus on syndromes impacting interventional radiology procedures.

Main Results:

  • Hypercoagulability is a significant factor in early thrombosis after arterial interventions.
  • Primary disorders stem from specific protein abnormalities.
  • Secondary syndromes are more numerous and diverse, affecting platelets, coagulation, fibrinolysis, blood vessels, and rheology.

Conclusions:

  • Understanding hypercoagulability is crucial for interventional radiologists.
  • Accurate diagnosis and management can prevent post-procedural complications.
  • Continued research refines understanding and treatment of these clotting disorders.

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