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Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Improvement in exercise-induced left ventricular dysfunction by infusion of alpha-human atrial natriuretic peptide in

M Ukai1, Y Nishinaka, T Sobue

  • 1First Department of International Medicine, Nagoya University, School of Medicine, Japan.

The American Journal of Cardiology
|March 1, 1995
PubMed

Insights

Recombinant alpha-human atrial natriuretic peptide (alpha-hANP) infusion effectively reduced pulmonary artery pressures and improved hemodynamics in men with coronary artery disease during exercise. This peptide shows promise for managing exercise-induced left ventricular dysfunction.

Area of Science:

  • Cardiology
  • Pharmacology
  • Exercise Physiology

Background:

  • Coronary artery disease (CAD) can lead to acute left ventricular dysfunction during exercise.
  • Atrial natriuretic peptide (ANP) plays a role in cardiovascular homeostasis.
  • Exercise increases endogenous alpha-human atrial natriuretic peptide (alpha-hANP) levels.

Purpose of the Study:

  • To investigate the effects of exogenous alpha-hANP infusion on hemodynamic responses during exercise in men with CAD.
  • To assess the impact of alpha-hANP on exercise-induced left ventricular dysfunction.

Main Methods:

  • 14 men with CAD underwent symptom-limited graded exercise tests.
  • Hemodynamic variables and plasma concentrations of alpha-hANP and cyclic GMP were measured.
  • Intravenous alpha-hANP infusion was administered to patients with elevated pulmonary artery wedge pressure during exercise.

Main Results:

  • Plasma alpha-hANP and cyclic GMP levels increased significantly with exercise and correlated positively with pulmonary artery wedge pressure.
  • Alpha-hANP infusion significantly decreased systolic and diastolic pulmonary artery pressures and pulmonary artery wedge pressure during exercise.
  • Heart rate increased, while systolic blood pressure, diastolic blood pressure, and vascular resistances decreased during alpha-hANP infusion.

Conclusions:

  • Exogenous alpha-hANP infusion effectively mitigates exercise-induced increases in pulmonary artery pressures and improves hemodynamic function in men with CAD.
  • Alpha-hANP may be a therapeutic option for patients experiencing left ventricular dysfunction during physical exertion.

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