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Systemic hemodynamics and renal function during long-term pathophysiological increases in circulating endothelin

F C Wilkins¹, A Alberola, H L Mizelle

¹Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216.

The American Journal of Physiology

|February 11, 1995

Summary

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Elevated endothelin levels significantly impact cardiovascular and renal function, causing hypertension and reduced blood flow. This study demonstrates endothelin

Area of Science:

Cardiovascular Physiology
Renal Physiology
Endocrinology

Background:

Endogenous plasma endothelin levels are elevated in chronic conditions.
The isolated effect of increased endothelin on long-term cardiovascular and renal function is unknown.

Purpose of the Study:

To investigate the long-term systemic hemodynamic and renal effects of a pathophysiological increase in plasma endothelin concentration.

Main Methods:

Infusion of endothelin-1 in chronically instrumented, conscious dogs for 8 days.
Monitoring of systemic hemodynamics, cardiac output, and renal function parameters.

Main Results:

A two- to threefold increase in plasma endothelin led to a 21% increase in mean arterial pressure.

Related Experiment Videos

Cardiac output decreased by 33% and total peripheral resistance doubled.

Renal vascular resistance increased, while glomerular filtration rate and renal plasma flow decreased.

Conclusions:

Pathophysiological levels of endothelin are crucial in regulating chronic cardiovascular and renal function.
Endothelin may mediate chronic hypertension in conditions with endothelial dysfunction.