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Mitomycin C suppresses aqueous human flow in cynomolgus monkeys
C Kee1, C D Pelzek, P L Kaufman
1Department of Ophthalmology and Visual Sciences, Medical School, University of Wisconsin, Madison.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|February 1, 1995
Summary
Episcleral application of mitomycin C modestly reduced aqueous humor flow in primates. Subconjunctival injections did not affect aqueous humor formation, suggesting a localized effect of mitomycin C.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Mitomycin C is used during glaucoma surgery.
- Its effect on aqueous humor formation is not fully understood.
Purpose of the Study:
- To investigate the effect of mitomycin C on aqueous humor formation in cynomolgus monkeys.
Main Methods:
- Animals received subconjunctival injections or episcleral application of mitomycin C.
- Aqueous humor flow was measured using fluorophotometry.
Main Results:
- Subconjunctival mitomycin C did not alter aqueous humor flow.
- Episcleral mitomycin C significantly reduced aqueous humor flow at 2 weeks (P < .01).
Conclusions:
- Episcleral mitomycin C can reduce aqueous humor flow in primates.
- This reduction may contribute to postoperative hypotony after glaucoma surgery.