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Hydroxyl radicals and DNA double-strand breaks in X-irradiated E. coli
1Department of Radiation Oncology & Nuclear Medicine, Hahnemann University, Philadelphia, Pennsylvania 19102.
Biochemical and Biophysical Research Communications
|February 27, 1995
Abstract:
We have used glycerol to study the relationship between hydroxyl radicals, one of the primary radiolytic products, and the production of DNA double-strand breaks in selected E. coli strains. Our results suggest that when bacteria are irradiated at doses up to about 120 Gray, hydroxyl radicals produce DNA lesions, but not double-strand breaks.