Related Experiment Videos
Epidemiology of celiac sprue: a community-based study
N J Talley1, M Valdovinos, T M Petterson
1Division of Gastroenterology and Internal Medicine, Mayo Clinic, Rochester, Minnesota.
The American Journal of Gastroenterology
|June 1, 1994
Summary
This study provides the first U.S. community data on celiac disease (CD), revealing a stable incidence of 1.2 per 100,000 person-years and excellent survival rates. Prevalence was estimated at 21.8 per 100,000.
Area of Science:
- Epidemiology
- Gastroenterology
- Public Health
Background:
- Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten.
- Limited epidemiologic data exists for celiac disease in the United States.
- Understanding the incidence and prevalence of CD is crucial for public health planning.
Purpose of the Study:
- To determine the frequency and outcomes of celiac disease diagnoses within a defined U.S. community.
- To establish baseline epidemiologic data for celiac disease in the United States.
Main Methods:
- Utilized the Rochester Epidemiology Project to identify all Olmsted County, Minnesota residents diagnosed with celiac disease between 1960 and 1990.
- Calculated age- and gender-adjusted incidence and estimated prevalence.
- Analyzed survival rates within the identified cohort.
Main Results:
- Identified 28 incident cases of celiac disease.
- Reported an overall age- and gender-adjusted incidence of 1.2 per 100,000 person-years.
- Found no significant changes in incidence over time, with rates increasing with age. Survival was high (96% at 5 years). Estimated prevalence was 21.8 per 100,000 in 1991.
Conclusions:
- This study presents the first comprehensive epidemiologic data on celiac disease in the United States.
- The findings indicate a stable incidence and favorable prognosis for celiac disease in this community.
- Establishes a foundation for future U.S.-based celiac disease research.