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Related Experiment Videos

In situ models, physico-chemical aspects

J M ten Cate1

  • 1Department of Cardiology and Endodontology, Academic Centre for Dentistry, Amsterdam, the Netherlands.

Advances in Dental Research
|July 1, 1994
PubMed
Summary

In situ intra-oral caries models reveal significant individual variations in demineralization and remineralization. These models help understand oral physiology and test preventive agents like fluoride toothpaste.

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Area of Science:

  • Oral biology
  • Dental research
  • Biomineralization

Background:

  • In situ intra-oral caries models are crucial for understanding oral physiological processes and verifying in vitro findings.
  • They serve as a bridge between laboratory research and clinical trials for preventive agents.

Purpose of the Study:

  • To detail knowledge of the oral ecosystem.
  • To verify conclusions from in vitro experiments.
  • To test preventive agents in a pre-clinical setting.

Main Methods:

  • Utilizing enamel and dentin specimens within intra-oral devices.
  • Measuring demineralization and remineralization rates over time.
  • Analyzing lesion characteristics and mineral content.

Main Results:

  • Significant inter-individual and intra-individual variability in de/remineralization was observed.
  • Enamel demineralization can reach up to 62 vol% microns/day; dentin up to 89 vol% microns/day.
  • Median remineralization rate with fluoride toothpaste is 0.7%/day, correlated with lesion extent.

Conclusions:

  • In situ models provide valuable insights into dynamic oral processes.
  • Individual variability is a key factor in de/remineralization.
  • Remineralization rates depend on lesion severity and available surface area for mineral deposition.

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