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Biochemical parameters as prognostic factors in prostatic adenocarcinoma
S Vesalainen1, P Lipponen, M Talja
1Department of Surgery, University of Kuopio, Finland.
Acta Oncologica (Stockholm, Sweden)
|January 1, 1995
Summary
Serum creatinine, alkaline phosphatase, and acid phosphatases are linked to prostate cancer progression and survival. These simple lab tests offer valuable prognostic information for patients with prostatic adenocarcinoma.
Area of Science:
- Oncology
- Biochemistry
- Urology
Background:
- Prognostic markers are crucial for managing prostatic adenocarcinoma.
- Serum levels of creatinine (CR), alkaline phosphatase (ALP), acid phosphatase (ACP), and tartrate-inhibitable acid phosphatase (TIAP) are potential biomarkers.
Purpose of the Study:
- To investigate the relationship between serum levels of CR, ALP, ACP, and TIAP and clinical parameters in prostatic adenocarcinoma.
- To determine the prognostic value of these serum markers in relation to Gleason score, TM-category, disease progression, and survival.
Main Methods:
- Serum levels of CR, ALP, ACP, and TIAP were measured in 325 prostatic adenocarcinoma patients.
- Patients were followed up for over 12 years.
- Statistical analyses, including univariate and Cox's multivariate analysis, were performed.
Main Results:
- Elevated serum levels of CR, ALP, ACP, and TIAP correlated with invasive and metastatic disease and high Gleason scores.
- All tested serum markers significantly predicted prognosis in univariate analysis.
- Multivariate analysis revealed independent prognostic value for serum creatinine (overall), ALP (M0 tumors), and TIAP (T1-2M0 tumors).
Conclusions:
- Serum CR, ALP, ACP, and TIAP levels provide significant prognostic information in prostatic adenocarcinoma.
- These laboratory tests can aid in predicting disease progression and survival.
- The findings support the use of these simple biomarkers in clinical decision-making for prostate cancer management.