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Related Experiment Videos

Post-transfusion chronic hepatitis C in children

S Matsuoka1, K Tatara, Y Hayabuchi

  • 1Department of Pediatrics, University of Tokushima, School of Medicine, Japan.

Journal of Paediatrics and Child Health
|December 1, 1994
PubMed
Summary

Children receiving blood transfusions before 1990 have a significant risk of hepatitis C virus (HCV) infection. Early screening is crucial for detecting chronic HCV in this vulnerable pediatric population.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Pediatric Surgery

Background:

  • Hepatitis C virus (HCV) poses a risk to recipients of blood products.
  • Blood screening for HCV antibodies began in 1990.

Purpose of the Study:

  • To assess the prevalence of HCV infection in children who underwent open-heart surgery and received blood products.
  • To evaluate the long-term outcomes of HCV infection in this cohort.

Main Methods:

  • Screening of 226 pediatric patients using second-generation enzyme-linked immunosorbent assay (ELISA) and alanine aminotransferase (ALT) levels.
  • Virologic (HCV RNA) and histologic assessments for seropositive individuals.

Main Results:

  • 14% (22/161) of patients receiving blood products before 1990 were HCV seropositive.

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  • No seropositive cases were found in patients who received blood products after 1990.
  • 45% (10/24) of seropositive patients had persistent HCV infection with ongoing hepatitis.
  • 55% (12/24) of seropositive patients showed resolved HCV infection with normal ALT levels.

    • Conclusions:

    • Children who received blood products before 1990 are at high risk for HCV infection.
    • Routine screening is essential for identifying chronic hepatitis C in pediatric patients with a history of blood product transfusion prior to donor screening.
    • Early detection and management of HCV are critical for preventing long-term liver damage in children.