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Related Experiment Videos

Genetic and environmental factors in scleroderma

A J Silman1, J Newman

  • 1ARC Epidemiology Research Unit, University of Manchester, UK.

Current Opinion in Rheumatology
|November 1, 1994
PubMed
Summary

Epidemiologic research on scleroderma investigates genetic and environmental factors. Current evidence suggests occupational links in some cases, but not silicone gel breast implants.

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Area of Science:

  • Rheumatology
  • Immunology
  • Epidemiology

Background:

  • Scleroderma research focuses on identifying its causes.
  • Genetic and environmental factors are under investigation.
  • The role of the major histocompatibility complex in antibody response is noted.

Purpose of the Study:

  • To review current epidemiologic research on scleroderma.
  • To assess potential genetic and environmental risk factors.
  • To evaluate the association between scleroderma and silicone gel breast implants.

Main Methods:

  • Review of recent epidemiologic studies on scleroderma.
  • Analysis of genetic and environmental factors.
  • Examination of data regarding silicone gel breast implants.

Main Results:

  • The genetic basis of scleroderma remains unclear.
  • An occupational origin is plausible for a subset of cases.
  • No evidence links silicone gel breast implants to scleroderma development.

Conclusions:

  • Scleroderma etiology likely involves complex genetic and environmental interactions.
  • Occupational exposures may contribute to scleroderma in some individuals.
  • Silicone gel breast implants are not identified as a risk factor for scleroderma.

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