Related Experiment Videos
Regulation by glucose availability of tension development and electrical activity in fetal and neonatal rat hearts
V Guarner1, E H Hernández, S J Moreno
1Department of Physiology, National Institute of Cardiology Ignacio Chávez, Mexico DF, Mexico.
Biology of the Neonate
|January 1, 1994
Abstract:
The aim of the present article was to study if changes in glucose availability modify the functional activity of the glucose-dependent developing heart. Our data indicate that a decrease in glucose availability increases tension development and action potential duration at early fetal stages. This fact could probably be explained by the enhancement of Ca2+ movements that regulate the number and turnover rate of membrane glucose transporters in muscle cells. The sensitivity to glucose availability decreases postnatally as the heart becomes fatty acid-dependent.