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Indomethacin treatment in amphotericin B induced nephrogenic diabetes insipidus
T Höhler1, G Teuber, R Wanitschke
1I. Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Germany.
The Clinical Investigator
|October 1, 1994
Abstract:
Nephrogenic diabetes insipidus (NDI) is a serious side effect of various drugs. Elevated renal prostaglandin E2 levels have been found in patients with lithium-induced NDI and have been implicated in the pathogenesis. We report the case of a patient who developed NDI following treatment with amphotericin B. Prostaglandin levels were elevated. Indomethacin had an antidiuretic effect and normalized prostaglandin levels.