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The 5' noncoding region and virulence of poliovirus vaccine strains
A J Macadam1, D M Stone, J W Almond
1Divn of Virology, National Institute for Biological Standards and Control, South Mimms, Herts., UK.
Trends in Microbiology
|November 1, 1994
Abstract:
All three live, attenuated vaccine strains of poliovirus contain important attenuation determinants in a short conserved sequence in the 5' noncoding region. Evidence suggests these act by weakening a secondary-structural element critical for the unusual mechanism of translational initiation of picornaviruses, in which ribosomes bind directly to a site far downstream of the 5' end. Understanding the molecular basis of attenuation may allow novel vaccine strains to be designed.